Representative Publications
Harnessing piezoelectric stimulation to modulate PI3K-AKT signaling for intervertebral disc regeneration
Yisi Liu, Jie Hu, Yu Qian, Qian Wu, Yan Su, Hao Jiang, Hui He, Qianglong Chen, Qifan Yu, Qiang Yang, Ting Liang, Caihong Zhu, Zhangqin Yuan*, Houfeng Zheng*, Fengxuan Han*, Bin Li*.
Pla2g7 regulates bone homeostasis via Alox12/12-HETE/Gpr31 signaling axis
Jiayan Jin, Zeyu Zheng, Jiaxuan Gu, Qibin Zhang, Zhikun Xu, Zhenhua Feng, Siyue Tao, Shumin He, Jiao Cheng, Jian Wang, Hou-Feng Zheng*, Shishi Li*, Fengdong Zhao* & Jian Chen*.
Genetically informed causal links between gut microbiota and bone mass: pleiotropy and metabolic mediation
Peng-Lin Guan, Cheng-Da Yuan, Ming-Yu Han, Yi-Hu Fang, Chun-Fu Yu, Pian-Pian Zhao, Yu Qian, Jiang-Wei Xia, Peng Wei, Cai-Rui Liu, Meng-Yuan Yang, Wei Xu, Ching-Lung Cheung, Shu-Yang Xie*, Fu-Sheng Zhou*, Xiao-Li Rong* & Hou-Feng Zheng*
A Complex FGF14 (TTC)/(TGC) Repeat Expansion in Parkinsons Disease
Xiaosheng Zheng, Zhidong Cen*, Xinhui Chen, Fan Zhang, Chenxin Ying, Nan Jin, Peng Liu, Yilin Chen, Haotian Wang, Jiaxiang Li, Joanne Trinh, Joshua Laß MSc, David Pellerin, MSc, Matt C. Danzi, Stephan Zuchner, Bernard Brais, Shen-Yang Lim, Ai Huey Tan, Azlina Ahmad-Annuar, Dehao Yang, Lebo Wang, Zhiru Lin, Fei Xie, Bo Wang, Sheng Wu, Zhiyuan Ouyang, Piu Chan, Shen Hu*, Christine Klein*, Hou-Feng Zheng*, Chaodong Wang*, Wei Luo*.
Genome-wide Association Studies of over 30,000 Samples with Bone Mineral Density at Multiple Skeletal Sites and Its Clinical Relevance.
Yu Qian, Jiangwei Xia, Pingyu Wang, Chao Xie, Hong-Li Lin, Gloria Hoi-Yee Li, Cheng-Da Yuan, Mo-Chang Qiu, Yi-Hu Fang, Chun-Fu Yu, Xiang-Chun Cai, Saber Khederzadeh, Pian-Pian Zhao, Meng-Yuan Yang, Jia-Dong Zhong, Xin Li, Peng-Lin Guan, Jia-Xuan Gu, Si-Rui Gai, Xiang-Jiao Yi, Jian-Guo Tao, Xiang Chen, Mao-Mao Miao, Guo-Bo Chen, Lin Xu, Shu-Yang Xie, Geng Tian, Hua Yue, Guangfei Li, Wenjin Xiao, David Karasik, Youjia Xu, Liu Yang, Ching-Lung Cheung, Fei Huang, Zhenlin Zhang, Hou-Feng Zheng*.
Enzyme-Programmable DNA-PEG Hydrogel Spatiotemporally Regulates Bone Regeneration Microenvironment
Xiang Wu, Fuxiao Wang, Ruiyang Li, Biao Yu, Tianhang Qi, Yunpeng Li, Xiao Chen, Jian Wang, Zhen Geng, Peiran Song, Long Bai, Dongyang Zhou, Hou-Feng Zheng*, Qin Zhang*, Jiacan Su*.
Dual PDE4/10A inhibition restores CREB1 function and enhances neuronal resilience in models of alzheimers disease.
Xiaoli Rong, Xia Yao, Haohui Fang, Johns Saji, Yu Qian, Jia-Xuan Gu, Meng-Yuan Yang, Peng Wei, Cai-Rui Liu, Bin Chen, Pian-Pian Zhao, Ching-Lung Cheung, Lin Bo, Hou-Feng Zheng*.
Atrazine exposure induces skeletal muscle atrophy: Multi-omics insights into mechanisms and therapeutic targets.
Jianguo Tao, Jiaxuan Gu, Maomao Miao, Guo-Bo Chen, Xueqin Hu, Sai Yao, Ou Wu, Taotao Xu, Huan Luo, Hongting Jin, Chengliang Wu, Peijian Tong, Hongfeng Ruan, Xiangjiao Yi, Hou-Feng Zheng*.
SEAD reference panel with 22,134 haplotypes boosts rare variant imputation and genome-wide association analysis in Asian populations
Yang MY, Zhong JD, Li X, Tian G, Bai WY, Fang YH, Qiu MC, Yuan CD, Yu CF, Li N, Yang JJ, Liu YH, Yu SH, Zhao WW, Liu JQ, Sun Y, Cong PK, Khederzadeh S, Zhao PP, Qian Y, Guan PL, Gu JX, Gai SR, Yi XJ, Tao JG, Chen X, Miao MM, Lei LX, Xu L, Xie SY, Li JC, Guo JF, Karasik D, Yang L, Tang BS, Huang F, Zheng HF*.
Shared genetic architecture highlights the bidirectional association between major depressive disorder and fracture risk.
Zhao PP, Ying ZM, Yuan CD, Zhang HS, Dong A, Tao JG, Yi XJ, Yang MY, Jin W, Tian WL, Karasik D, Tian G, Zheng HF*.
Deciphering the complex relationship between type 2 diabetes and fracture risk with both genetic and observational evidence.
Zhao PP, Sheng ZF, Xu L, Li P, Xiao WJ, Yuan CD, Xu ZW, Yang MY, Qian Y, Zhong JD, Gu JX, Karasik D, Zheng HF*.
Integrating both common and rare variants to predict bone mineral density and fracture.
Gai SR, Qian Y, Zhang ZL, Zheng HF*.
Ambient PM 2.5 Exposure and Bone Homeostasis: Analysis of UK Biobank Data and Experimental Studies in Mice and in Vitro.
Ge QW, Yang SJ, Qian Y, Chen JL, Yuan WH, Li SD, Wang PE, Li R, Zhang L, Chen GB, Kan HD, Rajagopalan S, Sun QH, Zheng HF*, Jin HT*, Liu CQ*.
Targeting sulfation-dependent mechanoreciprocity between matrix and osteoblasts to mitigate bone loss.
Zheng C, Liu H, Zhao PP, Lu WG, Song SJ, He T, Fan J, Wang D, Yang PF, Jie Q, Zheng HF*, Luo ZJ*, Yang L*.
Genomic analyses of 10,376 individuals in the Westlake BioBank for Chinese (WBBC) pilot project.
Cong PK, Bai WY, Li JC, Yang MY, Khederzadeh S, Gai SR, Li N, Liu YH, Yu SH, Zhao WW, Liu JQ, Sun Y, Zhu XW, Zhao PP, Xia JW, Guan PL, Qian Y, Tao JG, Xu L, Tian G, Wang PY, Xie SY, Qiu MC, Liu KQ, Tang BS*, Zheng HF*.
Identification of clinically actionable secondary genetic variants from whole-genome sequencing in a large-scale Chinese population.
Cong PK, Khederzadeh S, Yuan CD, Ma RJ, Zhang YY, Liu JQ, Yu SH, Xu L, Gao JH, Pan HX, Li JC, Xie SY*, Liu KQ*, Tang BS*, Zheng HF*.
Both indirect maternal and direct fetal genetic effects reflect the observational relationship between higher birth weight and lower adult bone mass.
Xia JW, Zhang L, Li J, Yuan CD, Zhu XW, Qian Y, Khederzadeh S, Gu JX, Xu L, Gao JH, Liu KQ, Karasik D, Xie SY, Chen GB, Zheng HF*.
General and abdominal obesity operate differently as influencing factors of fracture risk in old adults.
Zhu XW, Liu KQ, Yuan CD, Xia JW, Qian Y, Xu L, Gao JH, Rong XL, Chen GB, Karasik D, Xie SY, Zheng HF*.
Cohort profile: the Westlake BioBank for Chinese (WBBC) pilot project.
Zhu XW, Liu KQ, Wang PY, Liu JQ, Chen JY, Xu XJ, Xu JJ, Qiu MC, Sun Y, Liu C, Bai WY, Zhao PP, Xia J, Gai SR, Guan PL, Qian Y, Cong PK, Xie SY, Zheng HF*.
Observational and genetic evidence highlight the association of human sleep behaviors with the incidence of fracture.
Qian Y, Xia JW, Liu KQ, Xu L, Xie SY, Chen GB, Cong PK, Khederzadeh S, Zheng HF*.
Integrative analysis of genomic and epigenomic data reveal underlying superenhancer-mediated microRNA regulatory network for human bone mineral density.
Bai WY, Xia JW, Rong XL, Cong PK, Khederzadeh S, Zheng HF*.
Twelve years of GWAS discoveries for osteoporosis and related traits: advances, challenges and applications.
Zhu XW, Bai WY, Zheng HF*.
Systemic evaluation of the relationship between psoriasis, psoriatic arthritis and osteoporosis: observational and Mendelian randomisation study.
Xia J, Xie SY, Liu KQ, Xu L, Zhao PP, Gai SR, Guan PL, Zhao JQ, Zhu YP, Tsoi LC, Stuart PE, Nair RP, Yang HQ, Liao YT, Mao K, Qiu MC, Ying ZM, Hu B, Yang ZH, Bai WY, Zhu XW, Cong PK, Elder JT, Ye ZM, Wang B, Zheng HF*.
Identification of PIEZO1 polymorphisms for human bone mineral density.
Bai WY, Wang LJ, Ying ZM, Hu B, Xu L, Zhang GQ, Cong PK, Zhu XF, Zou WG*, Zheng HF*.
Genotype imputation and reference panel: a systematic evaluation on haplotype size and diversity.
Bai WY, Zhu XW, Cong PK, Zhang XJ, Richards JB, Zheng HF*.
Relationship between alcohol use, blood pressure and hypertension: an association study and a Mendelian randomisation study.
Zhao PP, Xu LW, Sun T, Wu YY, Zhu XW, Zhang B, Cheng Z, Cai X, Liu YC, Zhao TT, Wu TT, Ma HY, Wang L, Zhang XW, Yang L*, Zheng HF*.
Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study.
Trajanoska K, Morris JA, Oei L, Zheng HF, Evans DM, Kiel DP, Ohlsson C, Richards JB*, Rivadeneira F*; GEFOS/GENOMOS consortium and the 23andMe research team.
Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture.
Zheng HF, Forgetta V, Hsu YH, Estrada K, Rosello-Diez A, Leo PJ, Dahia CL, Park-Min KH, Tobias JH, Kooperberg C, Kleinman A, Styrkarsdottir U, Liu CT, Uggla C, Evans DS, Nielson CM, Walter K, Pettersson-Kymmer U, McCarthy S, Eriksson J, Kwan T, Jhamai M, Trajanoska K, Memari Y, Min J, Huang J,...…Rebecca D Jackson*, David W Rowe*, Cynthia A Loomis*, David M Evans*, Cheryl L Ackert-Bicknell *, Alexandra L Joyner*, Emma L Duncan*, Douglas P Kiel*, Fernando Rivadeneira*, J Brent Richards*, for the GEFOS and UK10K Consortia
Genetic structure of the Han Chinese population revealed by genome-wide SNP variation.
Chen JM, Zheng HF, Bei JX, Sun LD, Jia WH, Li T, Zhang FR, Seielstad M, Zeng YX, Zhang XJ, Liu JJ*.
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
Han JW, Zheng HF, Cui Y, Sun LD, Ye DQ, Hu Z, Xu JH, Cai ZM, Huang W, Zhao GP, Xie HF, Fang H, Lu QJ, Xu JH, Li XP, Pan YF, Deng DQ, Zeng FQ, Ye ZZ, Zhang XY, Wang QW, Hao F, Ma L, Zuo XB, Zhou FS, Du WH, Cheng YL, Yang JQ, Shen SK, Li J, Sheng YJ, Zuo XX, Zhu WF, Gao F, Zhang PL, Guo Q, Li B, Gao M, Xiao FL, Quan C, Zhang C, Zhang Z, Zhu KJ, Li Y, Hu DY, Lu WS, Huang JL, Liu SX, Li H, Ren YQ, Wang ZX, Yang CJ, Wang PG, Zhou WM, Lv YM, Zhang AP, Zhang SQ, Lin D, Li Y, Low HQ, Shen M, Zhai ZF, Wang Y, Zhang FY, Yang S, Liu JJ*, Zhang XJ*.
Full publications can be found here: https://scholar.google.com/citations?user=IO3IhW8AAAAJ&hl=en